PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways

Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for the degradation of poly(ADP-ribose). PARG dysfunction sensitizes cells to alkylating agents and induces cell death; however, the details of this effect have not been fully elucidated. Here, we investigated the mechanism by...

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Detalhes bibliográficos
Main Authors: Shirai, H, Poetsch, A R, Gunji, A, Maeda, D, Fujimori, H, Fujihara, H, Yoshida, T, Ogino, H, Masutani, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698538/
https://ncbi.nlm.nih.gov/pubmed/23744356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.133
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