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Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks
The combination of poly(ADP-ribose)polymerase (PARP) inhibitors and alkylating agents is currently being investigated in cancer therapy clinical trials. However, the DNA lesions producing the synergistic cell killing effect in tumors is not fully understood. Treatment of human and mouse fibroblasts...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2914189/ https://ncbi.nlm.nih.gov/pubmed/20573551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.05.007 |
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