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PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM
By limiting cell cycle progression following detection of DNA damage, checkpoints are critical for cell survival and genome stability. Methylated DNA damage, when combined with inhibition of PARP activity, results in an ATR-dependent S phase delay of the cell cycle. Here, we demonstrate that another...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763951/ https://ncbi.nlm.nih.gov/pubmed/19717351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.07.010 |
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