Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.
During stepwise increases in the methotrexate concentration in culture medium, we selected Chinese hamster ovary cells that contained elevated dihydrofolate reductase levels which were proportional to the number of dihydrofolate reductase gene copies (i.e., gene amplification). We studied the dihydr...
保存先:
| 出版年: | Mol Cell Biol |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
1981
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7346712/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.1.12.1069-1076.1981 |
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