Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.
During stepwise increases in the methotrexate concentration in culture medium, we selected Chinese hamster ovary cells that contained elevated dihydrofolate reductase levels which were proportional to the number of dihydrofolate reductase gene copies (i.e., gene amplification). We studied the dihydr...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1981
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369733/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7346712/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.1.12.1069-1076.1981 |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|