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Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.
Stable isolates of Chinese hamster ovary cells that are highly resistant to methotrexate have been selected in a multistep selection process. Quantitative immunoprecipitations have indicated that these isolates synthesize dihydrofolate reductase at an elevated rate over its synthesis in sensitive ce...
Gespeichert in:
| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1982
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6287233/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.2.3.275 |
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