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Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.

Stable isolates of Chinese hamster ovary cells that are highly resistant to methotrexate have been selected in a multistep selection process. Quantitative immunoprecipitations have indicated that these isolates synthesize dihydrofolate reductase at an elevated rate over its synthesis in sensitive ce...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Flintoff, W F, Weber, M K, Nagainis, C R, Essani, A K, Robertson, D, Salser, W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 1982
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369786/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6287233/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.2.3.275
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