Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.

Stable isolates of Chinese hamster ovary cells that are highly resistant to methotrexate have been selected in a multistep selection process. Quantitative immunoprecipitations have indicated that these isolates synthesize dihydrofolate reductase at an elevated rate over its synthesis in sensitive ce...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Flintoff, W F, Weber, M K, Nagainis, C R, Essani, A K, Robertson, D, Salser, W
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1982
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6287233/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.2.3.275-285.1982
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