CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Phosphatidylinositol-3-kinase p110δ serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell proliferation and survival. This provides a rationale for the development of small molecule inhibitors that selectively target p110δ as a treatment ap...

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Библиографические подробности
Главные авторы: Lannutti, Brian J., Meadows, Sarah A., Herman, Sarah E. M., Kashishian, Adam, Steiner, Bart, Johnson, Amy J., Byrd, John C., Tyner, Jeffrey W., Loriaux, Marc M., Deininger, Mike, Druker, Brian J., Puri, Kamal D., Ulrich, Roger G., Giese, Neill A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694505/
https://ncbi.nlm.nih.gov/pubmed/20959606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275305
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