Effects of Isoform-selective Phosphatidylinositol 3-Kinase Inhibitors on Osteoclasts: ACTIONS ON CYTOSKELETAL ORGANIZATION, SURVIVAL, AND RESORPTION

Phosphatidylinositol 3-kinases (PI3K) participate in numerous signaling pathways, and control distinct biological functions. Studies using pan-PI3K inhibitors suggest roles for PI3K in osteoclasts, but little is known about specific PI3K isoforms in these cells. Our objective was to determine effect...

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Detalhes bibliográficos
Main Authors: Shugg, Ryan P. P., Thomson, Ashley, Tanabe, Natsuko, Kashishian, Adam, Steiner, Bart H., Puri, Kamal D., Pereverzev, Alexey, Lannutti, Brian J., Jirik, Frank R., Dixon, S. Jeffrey, Sims, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853283/
https://ncbi.nlm.nih.gov/pubmed/24133210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507525
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