The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival

Cbl is an adaptor protein and an E3 ligase that plays both positive and negative roles in several signaling pathways that affect various cellular functions. Tyrosine 737 is unique to Cbl and is phosphorylated by Syk and Src family kinases. Phosphorylated Cbl Tyr(737) creates a binding site for the p...

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Bibliografische gegevens
Hoofdauteurs: Adapala, Naga Suresh, Barbe, Mary F., Langdon, Wallace Y., Nakamura, Mary C., Tsygankov, Alexander Y., Sanjay, Archana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
Onderwerpen:
Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978603/
https://ncbi.nlm.nih.gov/pubmed/20851882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.124628
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