Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy

Cbl and Cbl-b are E3 ubiquitin ligases and adaptor proteins, which perform regulatory roles in bone remodeling. Cbl−/− mice have delayed bone development due to decreased osteoclast migration. Cbl-b−/− mice are osteopenic due to increased bone resorbing activity of osteoclasts. Unique to Cbl, but no...

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Библиографические подробности
Главные авторы: Adapala, Naga Suresh, Holland, Danielle, Piccuillo, Vanessa, Barbe, Mary F., Langdon, Wallace Y., Tsygankov, Alexander Y., Lorenzo, Joseph A., Sanjay, Archana
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149851/
https://ncbi.nlm.nih.gov/pubmed/24994594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.06.013
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