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Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy
Cbl and Cbl-b are E3 ubiquitin ligases and adaptor proteins, which perform regulatory roles in bone remodeling. Cbl−/− mice have delayed bone development due to decreased osteoclast migration. Cbl-b−/− mice are osteopenic due to increased bone resorbing activity of osteoclasts. Unique to Cbl, but no...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4149851/ https://ncbi.nlm.nih.gov/pubmed/24994594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.06.013 |
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