PI3K/p110δ is a novel therapeutic target in multiple myeloma

In this study, we demonstrate expression and examined the biologic sequelae of PI3K/p110δ signaling in multiple myeloma (MM). Knockdown of p110δ by small interfering RNA caused significant inhibition of MM cell growth. Similarly, p110δ specific small molecule inhibitor CAL-101 triggered cytotoxicity...

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Autori principali: Ikeda, Hiroshi, Hideshima, Teru, Fulciniti, Mariateresa, Perrone, Giulia, Miura, Naoya, Yasui, Hiroshi, Okawa, Yutaka, Kiziltepe, Tanyel, Santo, Loredana, Vallet, Sonia, Cristea, Diana, Calabrese, Elisabetta, Gorgun, Gullu, Raje, Noopur S., Richardson, Paul, Munshi, Nikhil C., Lannutti, Brian J., Puri, Kamal D., Giese, Neill A., Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938837/
https://ncbi.nlm.nih.gov/pubmed/20505158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-222943
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