A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells

Constitutive B-cell lymphoma 6 (Bcl-6) expression was undetectable in multiple myeloma (MM) cell lines, except U266 cells. However, it was up-regulated by coculture with bone marrow (BM) stromal cell-culture supernatant (SCCS). Bcl-6 expression in patient MM cells in the BM was positive. Anti–interl...

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Detalhes bibliográficos
Main Authors: Hideshima, Teru, Mitsiades, Constantine, Ikeda, Hiroshi, Chauhan, Dharminder, Raje, Noopur, Gorgun, Gullu, Hideshima, Hiromasa, Munshi, Nikhil C., Richardson, Paul G., Carrasco, Daniel R., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865869/
https://ncbi.nlm.nih.gov/pubmed/20228272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-270082
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