Biologic sequelae of IκB kinase (IKK) inhibition in multiple myeloma: therapeutic implications

Nuclear factor-κB (NF-κB) has an important role in multiple myeloma (MM) cell pathogenesis in the context of the bone marrow (BM) microenvironment. In NF-κB signaling cascades, IκB kinase α (IKKα) and IKKβ are key molecules that predominantly mediate noncanonical and canonical pathways, respectively...

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Detalhes bibliográficos
Main Authors: Hideshima, Teru, Chauhan, Dharminder, Kiziltepe, Tanyel, Ikeda, Hiroshi, Okawa, Yutaka, Podar, Klaus, Raje, Noopur, Protopopov, Alexei, Munshi, Nikhil C., Richardson, Paul G., Carrasco, Ruben D., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686191/
https://ncbi.nlm.nih.gov/pubmed/19270264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-161505
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