Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Perifosine is a synthetic novel alkylphospholipid, a new class of antitumor agents which targets cell membranes and inhibits Akt activation. Here we show that baseline phosphorylation of Akt in multiple myeloma (MM) cells is completely inhibited by perifosine [octadecyl-(1,1-dimethyl-piperidinio-4-y...

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Main Authors: Hideshima, Teru, Catley, Laurence, Yasui, Hiroshi, Ishitsuka, Kenji, Raje, Noopur, Mitsiades, Constantine, Podar, Klaus, Munshi, Nikhil C., Chauhan, Dharminder, Richardson, Paul G., Anderson, Kenneth C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society of Hematology 2006
Ábhair:
Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895278/
https://ncbi.nlm.nih.gov/pubmed/16418332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3434
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