Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Perifosine is a synthetic novel alkylphospholipid, a new class of antitumor agents which targets cell membranes and inhibits Akt activation. Here we show that baseline phosphorylation of Akt in multiple myeloma (MM) cells is completely inhibited by perifosine [octadecyl-(1,1-dimethyl-piperidinio-4-y...

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Detalhes bibliográficos
Main Authors: Hideshima, Teru, Catley, Laurence, Yasui, Hiroshi, Ishitsuka, Kenji, Raje, Noopur, Mitsiades, Constantine, Podar, Klaus, Munshi, Nikhil C., Chauhan, Dharminder, Richardson, Paul G., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895278/
https://ncbi.nlm.nih.gov/pubmed/16418332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3434
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