Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

Honokiol (HNK) is an active component purified from magnolia, a plant used in traditional Chinese and Japanese medicine. Here we show that HNK significantly induces cytotoxicity in human multiple myeloma (MM) cell lines and tumor cells from patients with relapsed refractory MM. Neither coculture wit...

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Detalhes bibliográficos
Main Authors: Ishitsuka, Kenji, Hideshima, Teru, Hamasaki, Makoto, Raje, Noopur, Kumar, Shaji, Hideshima, Hiromasa, Shiraishi, Norihiko, Yasui, Hiroshi, Roccaro, Aldo M., Richardson, Paul, Podar, Klaus, Le Gouill, Steven, Chauhan, Dharminder, Tamura, Kazuo, Arbiser, Jack, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895215/
https://ncbi.nlm.nih.gov/pubmed/15870175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0346
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