Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo

Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine; trade name, Atiprimod) is an orally bioavailable cationic amphiphilic compound that significantly inhibits production of interleukin 6 (IL-6) and inflammation in rat arthritis and autoimmune animal models. We here characteri...

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Detalhes bibliográficos
Main Authors: Hamasaki, Makoto, Hideshima, Teru, Tassone, Pierfrancesco, Neri, Paola, Ishitsuka, Kenji, Yasui, Hiroshi, Shiraishi, Norihiko, Raje, Noopur, Kumar, Shaji, Picker, Donald H., Jacob, Gary S., Richardson, Paul G., Munshi, Nikhil C., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895034/
https://ncbi.nlm.nih.gov/pubmed/15705788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-09-3794
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