The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma

A critical role for vascular endothelial factor (VEGF) has been demonstrated in multiple myeloma (MM) pathogenesis. Here, we characterized the effect of the small-molecule VEGF receptor inhibitor pazopanib on MM cells in the bone marrow milieu. Pazopanib inhibits VEGF-triggered signaling pathways in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Podar, Klaus, Tonon, Giovanni, Sattler, Martin, Tai, Yu-Tzu, LeGouill, Steven, Yasui, Hiroshi, Ishitsuka, Kenji, Kumar, Shaji, Kumar, Rakesh, Pandite, Lini N., Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748251/
https://ncbi.nlm.nih.gov/pubmed/17164332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609329103
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