A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

Aurora-A is a mitotic kinase that regulates mitotic spindle formation and segregation. In multiple myeloma (MM), high Aurora-A gene expression has been correlated with centrosome amplification and proliferation; thus, inhibition of Aurora-A in MM may prove to be therapeutically beneficial. Here we a...

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Main Authors: Görgün, Güllü, Calabrese, Elisabetta, Hideshima, Teru, Ecsedy, Jeffrey, Perrone, Giulia, Mani, Mala, Ikeda, Hiroshi, Bianchi, Giada, Hu, Yiguo, Cirstea, Diana, Santo, Loredana, Tai, Yu-Tzu, Nahar, Sabikun, Zheng, Mei, Bandi, Madhavi, Carrasco, Ruben D., Raje, Noopur, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892955/
https://ncbi.nlm.nih.gov/pubmed/20382844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-259523
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