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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
[Image: see text] The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective, orally bioavailable inhibit...
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| Udgivet i: | ACS Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2015
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468408/ https://ncbi.nlm.nih.gov/pubmed/26101564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500409n |
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