Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and progression. MLN8054 is a selective small-molecule Aurora A kinase inhibitor that has entered Phase I clinical trials for advanced solid tumors...

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Detalhes bibliográficos
Main Authors: Manfredi, Mark G., Ecsedy, Jeffrey A., Meetze, Kristan A., Balani, Suresh K., Burenkova, Olga, Chen, Wei, Galvin, Katherine M., Hoar, Kara M., Huck, Jessica J., LeRoy, Patrick J., Ray, Emily T., Sells, Todd B., Stringer, Bradley, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Bolen, Joseph B., Claiborne, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820716/
https://ncbi.nlm.nih.gov/pubmed/17360485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608798104
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