Anti-myeloma activity of a multi targeted kinase inhibitor, AT9283, via potent Aurora Kinase and STAT3 inhibition either alone or in combination with lenalidomide

PURPOSE: Aurora Kinases, whose expression is linked to genetic instability and cellular proliferation, are under investigation as novel therapeutic targets in multiple myeloma (MM). Here, we investigated the preclinical activity of a small molecule–multi-targeted kinase inhibitor, AT9283, with poten...

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Detalhes bibliográficos
Main Authors: Santo, Loredana, Hideshima, Teru, Cirstea, Diana, Bandi, Madhavi, Nelson, Erik A., Gorgun, Gullu, Rodig, Scott, Vallet, Sonia, Pozzi, Samantha, Patel, Kishan, Unitt, Christine, Squires, Matt, Hu, Yiguo, Chauhan, Dharminder, Mahindra, Anuj, Munshi, Nikhil C., Anderson, Kenneth C., Raje, Noopur
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163546/
https://ncbi.nlm.nih.gov/pubmed/21430070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3012
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