AT7519, A NOVEL SMALL MOLECULE MULTI-CYCLIN DEPENDENT KINASE INHIBITOR, INDUCES APOPTOSIS IN MULTIPLE MYELOMA VIA GSK-3β ACTIVATION AND RNA POLYMERASE II INHIBITION

Dysregulated cell cycling is a universal hallmark of cancer and is often mediated by abnormal activation of cyclin dependent kinases (CDKs) and their cyclin partners. Overexpression of individual complexes are reported in multiple myeloma (MM), making them attractive therapeutic targets. Here we inv...

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Detalhes bibliográficos
Principais autores: Santo, Loredana, Vallet, Sonia, Hideshima, Teru, Cirstea, Diana, Ikeda, Hiroshi, Pozzi, Samantha, Patel, Kishan, Okawa, Yutaka, Gorgun, Gullu, Perrone, Giulia, Calabrese, Elisabetta, Yule, Murray, Squires, Matt, Ladetto, Marco, Boccadoro, Mario, Richardson, Paul G, Munshi, Nikhil C., Anderson, Kenneth C., Raje, Noopur
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183744/
https://ncbi.nlm.nih.gov/pubmed/20101221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.510
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