Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte Response

Selection for escape mutant immunodeficiency viruses by cytotoxic T lymphocytes (CTL) has been well characterized and may be associated with disease progression. CTL epitopes accrue escape mutations at different rates in vivo. Interestingly, certain high-frequency CTL do not select for escape until...

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Detalhes bibliográficos
Main Authors: Friedrich, Thomas C., Frye, Christopher A., Yant, Levi J., O'Connor, David H., Kriewaldt, Nancy A., Benson, Meghan, Vojnov, Lara, Dodds, Elizabeth J., Cullen, Candice, Rudersdorf, Richard, Hughes, Austin L., Wilson, Nancy, Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Recombination and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369222/
https://ncbi.nlm.nih.gov/pubmed/14963161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.5.2581-2585.2004
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