Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte Response

Selection for escape mutant immunodeficiency viruses by cytotoxic T lymphocytes (CTL) has been well characterized and may be associated with disease progression. CTL epitopes accrue escape mutations at different rates in vivo. Interestingly, certain high-frequency CTL do not select for escape until...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

I whakaputaina i:	J Virol
Ngā kaituhi matua:	Friedrich, Thomas C., Frye, Christopher A., Yant, Levi J., O'Connor, David H., Kriewaldt, Nancy A., Benson, Meghan, Vojnov, Lara, Dodds, Elizabeth J., Cullen, Candice, Rudersdorf, Richard, Hughes, Austin L., Wilson, Nancy, Watkins, David I.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Microbiology (ASM) 2004
Ngā marau:	Recombination and Evolution
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369222/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14963161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.5.2581-2585.2004
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!