Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost

Escape from specific T-cell responses contributes to the progression of human immunodeficiency virus type 1 (HIV-1) infection. T-cell escape viral variants are retained following HIV-1 transmission between major histocompatibility complex (MHC)-matched individuals. However, reversion to wild type ca...

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Main Authors: Fernandez, Caroline S., Stratov, Ivan, De Rose, Robert, Walsh, Katrina, Dale, C. Jane, Smith, Miranda Z., Agy, Michael B., Hu, Shiu-lok, Krebs, Kendall, Watkins, David I., O'Connor, David H., Davenport, Miles P., Kent, Stephen J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2005
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082732/
https://ncbi.nlm.nih.gov/pubmed/15827187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5721-5731.2005
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