Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8(+) T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell–mediated in vivo control of HIV-1. Primary HIV-1–specific T cel...

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Detalhes bibliográficos
Main Authors: Liu, Michael K.P., Hawkins, Natalie, Ritchie, Adam J., Ganusov, Vitaly V., Whale, Victoria, Brackenridge, Simon, Li, Hui, Pavlicek, Jeffrey W., Cai, Fangping, Rose-Abrahams, Melissa, Treurnicht, Florette, Hraber, Peter, Riou, Catherine, Gray, Clive, Ferrari, Guido, Tanner, Rachel, Ping, Li-Hua, Anderson, Jeffrey A., Swanstrom, Ronald, B, CHAVI Core, Cohen, Myron, Karim, Salim S. Abdool, Haynes, Barton, Borrow, Persephone, Perelson, Alan S., Shaw, George M., Hahn, Beatrice H., Williamson, Carolyn, Korber, Bette T., Gao, Feng, Self, Steve, McMichael, Andrew, Goonetilleke, Nilu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533301/
https://ncbi.nlm.nih.gov/pubmed/23221345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65330
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