Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8(+) T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell–mediated in vivo control of HIV-1. Primary HIV-1–specific T cel...

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Autors principals: Liu, Michael K.P., Hawkins, Natalie, Ritchie, Adam J., Ganusov, Vitaly V., Whale, Victoria, Brackenridge, Simon, Li, Hui, Pavlicek, Jeffrey W., Cai, Fangping, Rose-Abrahams, Melissa, Treurnicht, Florette, Hraber, Peter, Riou, Catherine, Gray, Clive, Ferrari, Guido, Tanner, Rachel, Ping, Li-Hua, Anderson, Jeffrey A., Swanstrom, Ronald, B, CHAVI Core, Cohen, Myron, Karim, Salim S. Abdool, Haynes, Barton, Borrow, Persephone, Perelson, Alan S., Shaw, George M., Hahn, Beatrice H., Williamson, Carolyn, Korber, Bette T., Gao, Feng, Self, Steve, McMichael, Andrew, Goonetilleke, Nilu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533301/
https://ncbi.nlm.nih.gov/pubmed/23221345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65330
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