Vertical T cell immunodominance and epitope entropy determine HIV-1 escape

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8(+) T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell–mediated in vivo control of HIV-1. Primary HIV-1–specific T cel...

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Autores principales: Liu, Michael K.P., Hawkins, Natalie, Ritchie, Adam J., Ganusov, Vitaly V., Whale, Victoria, Brackenridge, Simon, Li, Hui, Pavlicek, Jeffrey W., Cai, Fangping, Rose-Abrahams, Melissa, Treurnicht, Florette, Hraber, Peter, Riou, Catherine, Gray, Clive, Ferrari, Guido, Tanner, Rachel, Ping, Li-Hua, Anderson, Jeffrey A., Swanstrom, Ronald, B, CHAVI Core, Cohen, Myron, Karim, Salim S. Abdool, Haynes, Barton, Borrow, Persephone, Perelson, Alan S., Shaw, George M., Hahn, Beatrice H., Williamson, Carolyn, Korber, Bette T., Gao, Feng, Self, Steve, McMichael, Andrew, Goonetilleke, Nilu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533301/
https://ncbi.nlm.nih.gov/pubmed/23221345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65330
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