Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection

HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. We used single-genome amplification and sequencing of complete HIV genomes to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral se...

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Bibliographic Details
Main Authors: Ganusov, Vitaly V., Goonetilleke, Nilu, Liu, Michael K. P., Ferrari, Guido, Shaw, George M., McMichael, Andrew J., Borrow, Persephone, Korber, Bette T., Perelson, Alan S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187476/
https://ncbi.nlm.nih.gov/pubmed/21835793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00655-11
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