Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response

Human lymphocyte antigen (HLA)-restricted CD8(+) cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escap...

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Main Authors: Troyer, Ryan M., McNevin, John, Liu, Yi, Zhang, Shao Chong, Krizan, Randall W., Abraha, Awet, Tebit, Denis M., Zhao, Hong, Avila, Santiago, Lobritz, Michael A., McElrath, M. Juliana, Le Gall, Sylvie, Mullins, James I., Arts, Eric J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659432/
https://ncbi.nlm.nih.gov/pubmed/19343217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000365
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