Novel Cytotoxic T-Lymphocyte Escape Mutation by a Three-Amino-Acid Insertion in the Human Immunodeficiency Virus Type 1 p6(Pol) and p6(Gag) Late Domain Associated with Drug Resistance

Cytolytic T lymphocytes (CTL) play a major role in controlling human immunodeficiency virus type 1 (HIV-1) infection. To evade immune pressure, HIV-1 is selected at targeted CTL epitopes, which may consequentially alter viral replication fitness. In our longitudinal investigations of the interplay b...

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Detalhes bibliográficos
Main Authors: Cao, Jianhong, McNevin, John, McSweyn, Matthew, Liu, Yi, Mullins, James I., McElrath, M. Juliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224368/
https://ncbi.nlm.nih.gov/pubmed/17942528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01096-07
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