Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of the HLA-C Gene and Surface HLA-C Expression

Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (−35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across −35 SNP genotypes can be attributed primarily to the very low exp...

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Autores principales: Corrah, Tumena W., Goonetilleke, Nilu, Kopycinski, Jakub, Deeks, Steven G., Cohen, Myron S., Borrow, Persephone, McMichael, Andrew, Brackenridge, Simon
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067890/
https://ncbi.nlm.nih.gov/pubmed/21248048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02276-10
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