Pyrosequencing Reveals Restricted Patterns of CD8(+) T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus

CD8(+) T cells play a major role in the containment of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. CD8(+) T cell-driven variations in conserved regions under functional constraints result in diminished viral replicative capacity. While compensatory mutatio...

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Autori principali: Burwitz, Benjamin J., Sacha, Jonah B., Reed, Jason S., Newman, Laura P., Norante, Francesca A., Bimber, Benjamin N., Wilson, Nancy A., Watkins, David I., O'Connor, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Genetic Diversity and Evolution
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233179/
https://ncbi.nlm.nih.gov/pubmed/21994463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05650-11
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