Ultradeep Pyrosequencing Detects Complex Patterns of CD8(+) T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques

Human and simian immunodeficiency viruses (HIV/SIV) exhibit enormous sequence heterogeneity within each infected host. Here, we use ultradeep pyrosequencing to create a comprehensive picture of CD8(+) T-lymphocyte (CD8-TL) escape in SIV-infected macaques, revealing a previously undetected complex pa...

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Detalhes bibliográficos
Main Authors: Bimber, Benjamin N., Burwitz, Benjamin J., O'Connor, Shelby, Detmer, Ann, Gostick, Emma, Lank, Simon M., Price, David A., Hughes, Austin, O'Connor, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715741/
https://ncbi.nlm.nih.gov/pubmed/19515775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00897-09
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