Tertiary Mutations Stabilize CD8(+) T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus

Compensatory mutations offset fitness defects resulting from CD8(+) T lymphocyte (CD8(TL))-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag(181–189)CM9 CD8(TL) escape-associated compensator...

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Bibliographic Details
Main Authors: Burwitz, Benjamin J., Wu, Helen L., Reed, Jason S., Hammond, Katherine B., Newman, Laura P., Bimber, Benjamin N., Nimiyongskul, Francesca A., Leon, Enrique J., Maness, Nicholas J., Friedrich, Thomas C., Yokoyama, Masaru, Sato, Hironori, Matano, Tetsuro, O'Connor, David H., Sacha, Jonah B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957937/
https://ncbi.nlm.nih.gov/pubmed/24371068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03304-13
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