Tertiary Mutations Stabilize CD8(+) T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus

Compensatory mutations offset fitness defects resulting from CD8(+) T lymphocyte (CD8(TL))-mediated escape, but their impact on viral evolution following transmission to naive hosts remains unclear. Here, we investigated the reversion kinetics of Gag(181–189)CM9 CD8(TL) escape-associated compensator...

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Detalhes bibliográficos
Main Authors: Burwitz, Benjamin J., Wu, Helen L., Reed, Jason S., Hammond, Katherine B., Newman, Laura P., Bimber, Benjamin N., Nimiyongskul, Francesca A., Leon, Enrique J., Maness, Nicholas J., Friedrich, Thomas C., Yokoyama, Masaru, Sato, Hironori, Matano, Tetsuro, O'Connor, David H., Sacha, Jonah B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957937/
https://ncbi.nlm.nih.gov/pubmed/24371068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03304-13
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