CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

BACKGROUND: Virus-specific T cells are critical components in the containment of immunodeficiency virus infections. While the protective role of CD8+ T cells is well established by studies of CD8+ T cell-mediated viral escape, it remains unknown if CD4+ T cells can also impose sufficient selective p...

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Autors principals: Burwitz, Benjamin J, Giraldo-Vela, Juan Pablo, Reed, Jason, Newman, Laura P, Bean, Alexander T, Nimityongskul, Francesca A, Castrovinci, Philip A, Maness, Nicholas J, Leon, Enrique J, Rudersdorf, Richard, Sacha, Jonah B
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496649/
https://ncbi.nlm.nih.gov/pubmed/23131037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-91
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