CD8(+) T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness Defects In Vivo, and Many Revert after Transmission

Virus-specific CD8(+) T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex cl...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mudd, Philip A., Ericsen, Adam J., Walsh, Andrew D., León, Enrique J., Wilson, Nancy A., Maness, Nicholas J., Friedrich, Thomas C., Watkins, David I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209381/
https://ncbi.nlm.nih.gov/pubmed/21957309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05841-11
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky