Potent Antibody-Mediated Neutralization and Evolution of Antigenic Escape Variants of Simian Immunodeficiency Virus Strain SIVmac239 In Vivo

Here, we describe the evolution of antigenic escape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239. By 42 weeks postinfection, 50% neutralization of SIVmac239 was achieved with plasma dilutions of 1:1,000. Testing of purified immunoglobulin confi...

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Detalhes bibliográficos
Main Authors: Sato, Shuji, Yuste, Eloisa, Lauer, William A., Chang, Eun Hyuk, Morgan, Jennifer S., Bixby, Jacqueline G., Lifson, Jeffrey D., Desrosiers, Ronald C., Johnson, Welkin E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546989/
https://ncbi.nlm.nih.gov/pubmed/18667507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00871-08
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