Potent Antibody-Mediated Neutralization and Evolution of Antigenic Escape Variants of Simian Immunodeficiency Virus Strain SIVmac239 In Vivo

Here, we describe the evolution of antigenic escape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239. By 42 weeks postinfection, 50% neutralization of SIVmac239 was achieved with plasma dilutions of 1:1,000. Testing of purified immunoglobulin confi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sato, Shuji, Yuste, Eloisa, Lauer, William A., Chang, Eun Hyuk, Morgan, Jennifer S., Bixby, Jacqueline G., Lifson, Jeffrey D., Desrosiers, Ronald C., Johnson, Welkin E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546989/
https://ncbi.nlm.nih.gov/pubmed/18667507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00871-08
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge