CD8(+) T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness Defects In Vivo, and Many Revert after Transmission

Virus-specific CD8(+) T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex cl...

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Main Authors: Mudd, Philip A., Ericsen, Adam J., Walsh, Andrew D., León, Enrique J., Wilson, Nancy A., Maness, Nicholas J., Friedrich, Thomas C., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Genetic Diversity and Evolution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209381/
https://ncbi.nlm.nih.gov/pubmed/21957309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05841-11
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