Rhesus Cytomegalovirus-Specific CD8(+) Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection

CD8(+) cytotoxic T lymphocytes (CTLs) exert potent antiviral activity after HIV/SIV infection. However, efforts to harness the antiviral efficacy of CTLs for HIV/SIV prophylaxis and therapy have been severely hindered by two major problems: viral escape and exhaustion. By contrast, CTLs directed aga...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rosen, Brandon C., Pedreño-Lopez, Nuria, Ricciardi, Michael J., Reed, Jason S., Sacha, Jonah B., Rakasz, Eva G., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457070/
https://ncbi.nlm.nih.gov/pubmed/32922404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01960
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