Extralymphoid CD8(+) T Cells Resident in Tissue from Simian Immunodeficiency Virus SIVmac239Δnef-Vaccinated Macaques Suppress SIVmac239 Replication Ex Vivo

Live-attenuated vaccination with simian immunodeficiency virus (SIV) SIVmac239Δnef is the most successful vaccine product tested to date in macaques. However, the mechanisms that explain the efficacy of this vaccine remain largely unknown. We utilized an ex vivo viral suppression assay to assess the...

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Main Authors: Greene, Justin M., Lhost, Jennifer J., Burwitz, Benjamin J., Budde, Melisa L., Macnair, Caitlin E., Weiker, Madelyn K., Gostick, Emma, Friedrich, Thomas C., Broman, Karl W., Price, David A., O'Connor, Shelby L., O'Connor, David H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838091/
https://ncbi.nlm.nih.gov/pubmed/20089651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02028-09
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