Integrin α4β7 Is Downregulated on the Surfaces of Simian Immunodeficiency Virus SIVmac239-Infected Cells

Simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infection results in an early and enduring depletion of intestinal CD4(+) T cells. SIV and HIV bind integrin α4β7, thereby facilitating infection of lymphocytes that home to the gut-associated lymphoid tissue (GALT). Using an...

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Hlavní autoři: Budde, Melisa L., Lhost, Jennifer J., Dudley, Dawn M., Rakasz, Eva G., O'Connor, David H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903238/
https://ncbi.nlm.nih.gov/pubmed/20410278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00430-10
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