Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit

Benzobisthiazole derivatives were identified as novel helicase inhibitors through high throughput screening against purified S. aureus (Sa) and B. anthracis (Ba) replicative helicases. Chemical optimization has produced compound 59 with nanomolar potency against the DNA duplex strand unwinding activ...

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Autors principals: Li, Bing, Pai, Ramdas, Aiello, Daniel, Di, Ming, Barnes, Marjorie H., Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691018/
https://ncbi.nlm.nih.gov/pubmed/23664213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.055
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