Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit

Benzobisthiazole derivatives were identified as novel helicase inhibitors through high throughput screening against purified S. aureus (Sa) and B. anthracis (Ba) replicative helicases. Chemical optimization has produced compound 59 with nanomolar potency against the DNA duplex strand unwinding activ...

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Detalhes bibliográficos
Main Authors: Li, Bing, Pai, Ramdas, Aiello, Daniel, Di, Ming, Barnes, Marjorie H., Peet, Norton P., Bowlin, Terry L., Moir, Donald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691018/
https://ncbi.nlm.nih.gov/pubmed/23664213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.055
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