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Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit
Benzobisthiazole derivatives were identified as novel helicase inhibitors through high throughput screening against purified S. aureus (Sa) and B. anthracis (Ba) replicative helicases. Chemical optimization has produced compound 59 with nanomolar potency against the DNA duplex strand unwinding activ...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3691018/ https://ncbi.nlm.nih.gov/pubmed/23664213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.055 |
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