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Abnormal accumulation and recycling of glycoproteins visualized in Niemann–Pick type C cells using the chemical reporter strategy

Niemann–Pick type C (NPC) disease is characterized by impaired cholesterol efflux from late endosomes and lysosomes and secondary accumulation of lipids. Although impaired trafficking of individual glycoproteins and glycolipids has been noted in NPC cells and other storage disorders, there is curren...

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Autors principals: Mbua, Ngalle Eric, Flanagan-Steet, Heather, Johnson, Steven, Wolfert, Margreet A., Boons, Geert-Jan, Steet, Richard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690855/
https://ncbi.nlm.nih.gov/pubmed/23733943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221105110
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