ARF6-Mediated Endosome Recycling Reverses Lipid Accumulation Defects in Niemann-Pick Type C Disease

In human Niemann-Pick Type C (NPC) disease, endosomal trafficking defects lead to an accumulation of free cholesterol and other lipids in late endosome/lysosome (LE/LY) compartments, a subsequent block in cholesterol esterification and significantly reduced cholesterol efflux out of the cell. Here w...

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Bibliographic Details
Main Authors: Schweitzer, Jill Kuglin, Pietrini, Sean D., D'Souza-Schorey, Crislyn
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664925/
https://ncbi.nlm.nih.gov/pubmed/19365558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005193
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