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An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration
We describe a novel role for the ARF6 GTPase in the regulation of adherens junction (AJ) turnover in MDCK epithelial cells. Expression of a GTPase-defective ARF6 mutant, ARF6(Q67L), led to a loss of AJs and ruffling of the lateral plasma membrane via mechanisms that were mutually exclusive. ARF6-GTP...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125602/ https://ncbi.nlm.nih.gov/pubmed/11532961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.17.4973 |
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