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Elevated Endosomal Cholesterol Levels in Niemann-Pick Cells Inhibit Rab4 and Perturb Membrane Recycling

In normal human skin fibroblasts (HSFs), fluorescent glycosphingolipid analogues are endocytosed and sorted into two pools, one that is recycled to the plasma membrane and one that is transported to the Golgi complex. Here, we investigated glycosphingolipid recycling in Niemann-Pick type A and C lip...

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Detalhes bibliográficos
Main Authors: Choudhury, Amit, Sharma, Deepak K., Marks, David L., Pagano, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC519144/
https://ncbi.nlm.nih.gov/pubmed/15292453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-05-0432
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